{"id":8369,"date":"2021-04-14T17:42:16","date_gmt":"2021-04-14T15:42:16","guid":{"rendered":"https:\/\/usamedical.com\/sk\/?p=346"},"modified":"2021-04-14T17:42:16","modified_gmt":"2021-04-14T15:42:16","slug":"epidiolex-jedine-schvalene-cbd-liecivo","status":"publish","type":"post","link":"https:\/\/usamedical.com\/sk\/epidiolex-jedine-schvalene-cbd-liecivo\/","title":{"rendered":"EPIDIOLEX\u00ae \u2013 JEDIN\u00c9 SCHV\u00c1LEN\u00c9 CBD LIE\u010cIVO"},"content":{"rendered":"

EPIDYOLEX\u00ae od firmy GW Pharmaceuticals<\/a> je jedin\u00e9 CBD lie\u010divo pr\u00edrodn\u00e9ho p\u00f4vodu, ktor\u00e9 schv\u00e1lila Eur\u00f3pska agent\u00fara pre lieky (EMA). Je schv\u00e1len\u00fd na lie\u010dbu z\u00e1chvatov spojen\u00fdch s Lennox-Gastautov\u00fdm syndr\u00f3mom (LGS), Dravetovej syndr\u00f3mu alebo komplexom tuber\u00f3znej skler\u00f3zy (TSC) u pacientov vo veku od 1 roka.<\/p>\n

Pozrime sa spolo\u010dne \u010do obsahuje, ak\u00e9 s\u00fa \u00fa\u010dinky toho lie\u010diva a v \u010dom sa l\u00ed\u0161i od CBD v\u00fd\u017eivov\u00fdch doplnkov. <\/p>\n

Ako sa CBD liek u\u017e\u00edva?<\/b><\/h2>\n

U\u017e\u00edvanie CBD lieku Epidyolex je viazan\u00fd na lek\u00e1rsky predpis. Epidyolex je dostupn\u00fd ako kvapalina obsahuj\u00faca 100 mg kanabidiolu na ml. CBD sa u\u017e\u00edva pravidelne s jedlom alebo po\/pred jedlom. Odpor\u00fa\u010dan\u00e1 za\u010diato\u010dn\u00e1 d\u00e1vka je 2,5 mg na kilogram telesnej hmotnosti pod\u00e1van\u00e1 dvakr\u00e1t denne. Pri 70 kg osobe je to 175 mg CBD a to je skoro 2 ml CBD oleja. D\u00e1vky sa meraj\u00fa  injek\u010dnou strieka\u010dkou v balen\u00ed a u\u017e\u00edvaj\u00fa peror\u00e1lne (\u00fastami). Po jednom t\u00fd\u017edni sa d\u00e1vka zvy\u0161uje na 5 mg \/ kg CBD dvakr\u00e1t denne. V z\u00e1vislosti od individu\u00e1lnej odpovede organizmu, m\u00f4\u017ee lek\u00e1r d\u00e1vku postupne zvy\u0161ova\u0165 a\u017e na maximum 10 mg\/kg dvakr\u00e1t denne.<\/p>\n

Ak\u00fdm sp\u00f4sobom CBD liek \u00fa\u010dinkuje?<\/b><\/h2>\n

Aj ke\u010f sp\u00f4sob fungovania CBD na organizmus nie je presne pochopen\u00fd, predpoklad\u00e1 sa, \u017ee \u00fa\u010dinn\u00e1 l\u00e1tka v CBD zohr\u00e1va \u00falohu pri ovplyvnen\u00ed koncentr\u00e1cie v\u00e1pnika (Ca) v bunk\u00e1ch. V\u00e1pnik v bunk\u00e1ch je d\u00f4le\u017eit\u00fd v prenose elektrick\u00fdch sign\u00e1lov v nervov\u00fdch bunk\u00e1ch. Pri r\u00f4znych ochoreniach s\u00fa z\u00e1chvaty sp\u00f4soben\u00e9 nadmernou elektrickou aktivitou v mozgu (prenos elektr\u00f3nov \/ vzruchov v mozgu). Predpoklad\u00e1 sa, \u017ee CBD ovplyv\u0148uje zmenu koncentr\u00e1cie v\u00e1pnika, \u010d\u00edm zni\u017euje \u0161ancu z\u00e1chvatov pri Lennox-Gastautov\u00fdm syndr\u00f3mom (LGS) alebo Dravetovej syndr\u00f3mom. Predpoklad\u00e1 sa, \u017ee CBD okrem koncentr\u00e1cie v\u00e1pnika ovplyv\u0148uje adenoz\u00edn (chemick\u00fd posol v mozgu), ktor\u00fd hr\u00e1 d\u00f4le\u017eit\u00fa \u00falohu pri potl\u00e1\u010dan\u00ed z\u00e1chvatov.<\/p>\n

Ak\u00e9 v\u00fdsledky preuk\u00e1zali \u0161t\u00fadie? <\/b><\/h2>\n

Po\u010das schva\u013eovania CBD lieku v E\u00da (EMA) a USA (FDA) sa brali do \u00favahy hlavne \u0161tyri nosn\u00e9 \u0161t\u00fadie, ktor\u00e9 zah\u0155\u0148ali vzorku 715 pacientov s Lennox-Gastautov\u00fdm a Dravetovej syndr\u00f3mom. T\u00fdmto pacientom sa aplikoval CBD liek Epidyolex, spolu s in\u00fdmi liekmi na epilepsiu. Uk\u00e1zalo sa, \u017ee Epidyolex zn\u00ed\u017eil po\u010det z\u00e1chvatov po 14 t\u00fd\u017ed\u0148och u\u017e\u00edvania u pacientov, ktor\u00ed tie\u017e u\u017e\u00edvali aj  Clobazam<\/a>.<\/p>\n

V prv\u00fdch dvoch \u0161t\u00fadi\u00e1ch do\u0161lo u pacientov s Lennox-Gastautov\u00fdm syndr\u00f3mom pri u\u017e\u00edvan\u00ed Epidyolexu v kombin\u00e1cii s Clobazam k zn\u00ed\u017eeniu po\u010dtu z\u00e1chvatov a\u017e o 64% v porovnan\u00ed s placebom Clobazamom.<\/p>\n

V dvoch \u010fal\u0161\u00edch \u0161t\u00fadi\u00e1ch u pacientov s Dravetovej syndr\u00f3mom bolo zn\u00ed\u017eenie po\u010dtu konvulz\u00edvnych z\u00e1chvatov (ve\u013ek\u00e9 z\u00e1chvaty so stratou vedomia) a\u017e 61% u pacientov u\u017e\u00edvaj\u00facich Epidyolex a Clobazam, v porovnan\u00ed s u\u017e\u00edvan\u00edm placeba a Clobazamu.<\/p>\n

S\u00fa rizik\u00e1 pri u\u017e\u00edvan\u00ed CBD lieku?<\/b><\/h2>\n

Najbe\u017enej\u0161ie ved\u013eaj\u0161ie \u00fa\u010dinky lieku Epidyolex (ktor\u00e9 m\u00f4\u017eu postihn\u00fa\u0165 viac ako 1 z 10 \u013eud\u00ed) s\u00fa ospalos\u0165, zn\u00ed\u017een\u00e1 chu\u0165 do jedla, hna\u010dka, hor\u00fa\u010dka, \u00fanava a zvracanie. <\/p>\n

Najbe\u017enej\u0161\u00edm d\u00f4vodom ukon\u010denia lie\u010dby bola zv\u00fd\u0161en\u00e1 hladina pe\u010de\u0148ov\u00fdch enz\u00fdmov v krvi (zn\u00e1mka probl\u00e9mov s pe\u010de\u0148ou). <\/p>\n

Epidyolex sa nesmie pou\u017e\u00edva\u0165 u pacientov, ktor\u00fdch hladiny pe\u010de\u0148ov\u00fdch enz\u00fdmov v krvi s\u00fa viac ako trojn\u00e1sobok norm\u00e1lneho limitu a ktor\u00e9 maj\u00fa tie\u017e vy\u0161\u0161iu hladinu bilirub\u00ednu (marker probl\u00e9mov s pe\u010de\u0148ou) viac ako dvojn\u00e1sobok norm\u00e1lneho limitu. <\/p>\n

Zoznam v\u0161etk\u00fdch ved\u013eaj\u0161\u00edch \u00fa\u010dinkov pozorovan\u00fdch pri lie\u010dbe liekom Epidyolex sa nach\u00e1dza v p\u00edsomnej inform\u00e1cii pre pou\u017e\u00edvate\u013eov.<\/p>\n

Pr\u00edznaky pe\u010de\u0148ov\u00fdch riz\u00edk u\u017e\u00edvania CBD lieku<\/b><\/h3>\n

Medzi pr\u00edznaky probl\u00e9mov s pe\u010de\u0148ou patria:<\/p>\n